Michiel Verhulst (°1994) studied at the KU Leuven and obtained a Bachelor of Laws (2015, magna cum laude), a Master of Economics, Law and Business Studies (2017, summa cum laude with congratulations of the Board of Examiners) and a Master of Laws (2020, summa cum laude). During his studies he was a member of LCM Student Association, participated in several honour programs of the KU Leuven and was an intern at Belgian law firms. In 2017 he undertook an Erasmus exchange at the Management Center Innsbruck. His master thesis focused on a comparison of limited liability companies and a pledge and non-recourse loan on the one hand and on a principal-agent problem in the charitable sector on the other hand. For this he was awarded the Prijs Dieterfonds Rechtseconomie. Since September 2017 he started his doctoral research on the private enforcement of EU competition law (focusing on the quantification of damages) at the Centre for Methodology of Law. To complete this research, he was awarded a Fellowship by the Research Foundation - Flanders (FWO) in 2019.

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    Grulke, O;Acton, G;Adamek, J;Aggelis, D;Alamo-Calderon, R-M;Albert, C;Aleynikov, P;Aleynikova, K;Alonso, A;Amanekwe, GC;Anda, G;Andreeva, T;Andrew, E;Arkuszewski, A;Arnold, S;Arranz, M;Arvanitou, M;Ascasibar, E;Etxezarreta, M Astrain;Asztalos, O;Avramidis, K;Aymerich, E;Baciero, A;Baehner, J-P;Baek, S-G;Balden, M;Baldzuhn, J;Ballinger, S;Banduch, M;Bannmann, S;Navarro, A Banon;Baylor, L;Benndorf, A;Beidler, CD;Beiersdorf, D;de Beij, M;van Berkel, M;Bertelli, N;Biedermann, C;Bieg, B;Biewer, TM;Birkenmeier, G;Bjoerk, L;Blackwell, B;Blank, H;Bluhm, T;Boeckenhoff, D;Boeyaert, D;Bold, D;Bonciarelli, A;Bongiovi, G;Borchardt, M;Borodin, D;Bosman, T;Boumendjel, Y;Bouvain, H;Bozhenkov, S;Braeuer, T;Brandt, C;Brezinsek, S;Brunner, KJ;Buhler, A;Buller, S;Burton, L;Bueschel, C;Bussiahn, R;Buttenschoen, B;Buzas, A;Bykov, V;Cai, J;Calvo, I;Cappa, A;Carls, A;Carovani, F;Carr, M;Carralero, D;Carroll, T;de Carvalho, BB;Casas, JR;Castano-Bardawil, D;Cavalier, J;Cavazzana, R;Chaudhary, N;Chelis, I;Cipciar, D;Conway, G;Cordella, F;Corre, Y;Costello, P;Crombe, K;Cseh, G;Csillag, B;Castillo, HI Cu;Czymek, G;Damm, H;Davies, RJ;Degenkolbe, S;Dekeyser, W;Delgado-Aparicio, L;Demby, A;Desgranges, C;Dhard, C-P;Dinklage, A;Dittmar, T;Dittrich, L;Draeger, S;Dreval, M;Drevlak, M;Droste, J;Duligal, RK;Dumortier, P;Dunai, D;Edlund, E;Edmondson, A;van Eeten, P;Ehrke, G;Endler, M;Ennis, DA;Escoto, FJ;Estrada, T;Faber, B;Federici, F;Fellinger, J;Feng, Y;Fernando, DL;Fischer, S;Ford, OP;Fornal, T;Frank, J;Frerichs, H;Fuchert, G;Fujii, K;Fukuyama, M;Galdon Quiroga, J;Gallego Llorente, J;Gao, Y;Garcia, K;Garcia, OE;Garcia-Munoz, M;Garcia Regana, JM;Geiger, B;Geiger, J;Geissler, P;Gerard, M;Giudicotti, L;Gonda, T;Gonzalez, JC;Gonzalez Ganzabal, A;Goodman, A;Goriaev, A;Gradic, D;Grahl, M;Grasser, M;Grekov, D;Grelier, E;Grenfel, G;Griener, M;Groth, M;Gruca, M;Gudicotti, F;Arnaiz, JF Guerrero;Haak, V;de Haas, M;Haeussler, A;Hakola, A;van Ham, L;Hammond, KC;Hamstra, B;Han, X;Hansen, SK;Harris, A;Harris, JH;Harting, D;Hartmann, D;Hathiramani, D;Hausten, EV;Heinrich, S;Helander, P;Held, G;Henderson, P;Henke, F;Henneberg, SA;Henschke, L;Herold, F;Hillebrecht, H;Hinson, E;Hirsch, M;Hoffmeister, A;Holtz, A;Hoermann, SJ;Hoeschen, D;Houry, M;Hromadka, J;Hua, J;Huang, X;Hunger, K;Hwangbo, D;Ida, K;Igitkhanov, Y;Iglesias Fernandez, S;Igochine, V;Ioannidis, Z;d'Isa, FA;Jablonski, S;Jablonski, B;Jakubowski, M;Jenko, F;Johansson, A;Johnson, C;van Kaathoven, TCW;Kaczmarczyk, J;Kajita, S;Kallmeyer, J-P;Kasahara, H;Kasparek, W;Kawan, C;Kazakov, Ye O;Keller, SA;Kenmochi, N;Kernbichler, W;Kharwandikar, AK;Khokhlov, M;Killer, C;Kirschner, A;Kleiber, R;Klepper, CC;Klinger, T;Knauer, J;Knaup, M;Knieps, A;Kobayashi, M;Kocsis, G;Koelbl, M;Kolesnichenko, Y;Koenies, A;Kontula, J;Kornejew, P;Kovtun, Y;Kozulia, M;Kraemer-Flecken, A;Krause, M;Kremeyer, T;Krier, L;Kriete, DM;Krings, T;Krychowiak, M;Ksiazek, I;Kubkowska, M;Kulla, D;Kulyk, Y;Kumar, A;Kunkel, F;Kurki-Suonio, T;Kuzmych, I;Kwak, S;Laguardia, L;Langenberg, A;Laqua, H;Laqua, HP;Leche, K;Lee, B;Lee, W;Leyh, H;Liang, Y;Liao, L;Licchelli, M;Lin, Z;Lisaj, M;Litnovsky, A;Litovoli, F;Loizu, J;Lomanowski, B;Lopez Cansino, R;Lopez Miranda, B;Lopez-Rodriguez, D;Lore, J;Lorenz, A;Louwe, J;de la Luna, E;Lunsford, R;Luo, Y;Lutsenko, V;Maaziz, N;Machielsen, M;Mackenbach, R;Madeira, M;Makowski, D;Manz, P;Maragkoudakis, E;Marchuk, O;Marinoni, A;Markl, M;Marsen, S;Martinez Fernandez, J;Martseniuk, Y;Marushchenko, N;Masuzaki, S;Matsheza, S;Maurer, D;Mayer, M;Mazur, D;McCarthy, K;McCormack, O;McNeely, P;Medina Roque, D;Meineke, J;Meitner, S;Menzel-Barbara, A;van Milligen, B;Misdanitis, S;Mishchenko, A;Mitteau, R;Moeyaert, E;Mohammed, AI;Moiseenko, VE;Moeller, A;Moeller, S;Molnar, B;Moncada, V;Morfin-Guerrero, D;Morren, MCL;Moseev, D;Motojima, G;Mulas, S;Mulholland, P;Murugesan, V;Nagel, M;Nagy, D;Nair, V;Narbutt, Y;Naujoks, D;Neilson, HG;Nespoli, F;Neu, G;Neu, R;Neubauer, O;Neuner, U;Ngo, SK;Nicolai, D;Nielsen, SK;Nikulsin, N;Nishizawa, T;Nitzsche, L;Nuehrenberg, C;Ochoukov, R;Offermanns, G;Ogawa, K;Ongena, J;Oosterbeek, JW;Otte, M;Overduin, E;Pablant, N;Pacios, L;Panadero, N;Pandey, A;Parks, K;Partesotti, G;Pasch, EA;de Pascuale, S;Pavlichenko, R;Pavone, A;Pawelec, E;de la Pena Gomez, A;Pereira, A;Perseo, V;Peterson, B;Pisano, F;Pitcher, S;Plaum, B;Plunk, G;Podavini, L;Polei, NS;Poloskei, P;Ponomarenko, S;Pons-Villalonga, P;Popov, A;Porkolab, M;Proll, JHE;Pueschel, MJ;Raak, A;Ragona, R;Rahbarnia, K;Rasinski, M;Rasmussen, J;Raths, O;Rattawongnara, E;Refy, D;Reimold, F;Richert, T;Richou, M;Ricken, J;Riemann, JS;Risse, K;de la Riva Villen, J;Roberg-Clark, G;Rodriguez, E;Rogge, C;Rohde, V;Romazanov, J;Romba, T;Rondeshagen, D;Rong, P;Rud, M;Rummel, T;Runov, A;Rust, N;Ryc, L;Ryndyk, D;Sakai, H;Salewski, M;Sanchez, E;Sanchez, L Sanchis;Satake, S;Satheeswaran, G;Schacht, J;Scharff, E;Scharmer, F;Schlisio, G;Schmid, K;Schmidt, BS;Schmidt, GL;Schmitz, O;Schneider, M;Schroeder, T;Schroeder, R;Schuelke, M;Schweer, B;Sereda, S;Shanahan, B;Shin, J;Shiraiwa, S;Sias, G;Sichta, P;Siddiki, FBT;Simko, S;Singh, L;Sipilae, S;Slaby, C;Sleczka, M;Smith, B;Smith, DR;Smith, HM;Smoniewski, J;Spolaore, M;Spring, A;Stange, T;von Stechow, A;Steinbrunner, P;Stepanov, I;Stephey, L;Stroth, U;Suzuki, C;Suzuki, Y;Swee, C;Syrocki, L;Szepesi, T;Szymanski, M;Takahashi, H;Tamura, N;Tanaka, K;Tantos, C;Thiede, S;Thienpondt, H;Thomsen, H;Thun, T;Togo, S;Tork, T;Torkler, M;Mora, H Trimino;Tsikouras, A;Valougeorgis, D;Varoutis, S;Vavrik, M;Mendes, S Vaz;Vecsei, M;Velasco, JL;Versemann, L;Verstraeten, M;Vervier, M;Vianello, N;Viezzer, E;Villalobos-Granados, E-M;Wagner, J;Wang, E;Wappl, M;Warmer, F;Wegner, Th;Wei, W;Weir, G;Wendler, N;White, A;Willensdorfer, M;Windisch, T;Winter, A;Winters, V;Wischmeier, M;de Wolf, R;Wolf, RC;Wright, J;Wurden, G;Xanthopoulos, P;Xu, S;Yamada, H;Yan, X;Yang, J;Yang, Y;Ye, K;Yokoyama, M;Yoshinuma, M;Zamorski, B;Zanini, M;Zarnstorff, M;Zhang, D;Zhu, C;Zilker, M;Zimmermann, J;Zocco, A;Zohm, H;Zoletnik, S; 2026. Overview of Wendelstein 7-X high-performance operation. Nuclear Fusion; 2026; Vol. 66; iss. 11
    LIRIAS4426282
    description

    Publisher: IOP Publishing Ltd
    Accepted
  • journal-article
    Theiler, C;Adamek, J;Agostini, M;Albert, C;Alberti, S;Alberti, G;Aleiferis, S;Alessi, E;Anastassiou, G;Andrebe, Y;Antonenas, Y;Apruzzese, GM;Aucone, L;Auriemma, F;Ayllon-Guerola, J;Aymerich, E;Bagnato, F;Bairaktaris, F;Balestri, A;Ball, J;Balugani, S;Baquero-Ruiz, M;Bardsley, O;Battey, AF;Bauer, T;Bechtle, S;Bernert, M;Bin, W;Blanchard, P;Boedo, J;Bolzonella, T;Bonalumi, L;Bonisolli, M;Bosman, T;Bouffet-Klein, R;Boyer, MD;Bramucci, L;Braunmuller, F;Breizman, BN;Brida, D;Brown, B;Brunner, S;Buchli, J;Buermans, J;Busi, D;Camenen, Y;Cardinali, A;Carli, S;Carnevale, D;Carpanese, F;Carpita, M;Casolari, A;Castaldo, C;Cavedon, M;Cazabonne, J;Cerovsky, J;Chapman-Oplopoiou, B;Chellai, O;Chervonyi, Y;Chlum, J;Chmielewski, P;Chomiczewska, A;Cicioni, R;Ciraolo, G;Classen, I;Clod, A;Coda, S;Colandrea, C;Contre, CE;Coosemans, R;Cordaro, L;Cornelissen, M;Craciunescu, T;Cruz Zabala, DJ;Czarski, M;Davies, I;Dawson, C;De Tommasi, G;De Vylder, B;Decker, J;Derks, GL;Devlaminck, E;Di Giannatale, G;di Grazia, LE;Ding, R;Donner, C;Dreval, M;Dritselis, C;Dubbioso, S;Ducker, R;Dunne, M;Durr-Legoupil-Nicoud, G;Duval, BP;Edes, L;Ernst, S;Faitsch, M;Fan, C;Fasoli, A;Fedorczak, N;Felici, F;Ferron, N;Ficker, O;Figini, L;Figueiredo, P;Frank, A;Frassinetti, L;Frattolillo, D;Frigione, D;Furno, I;Fevrier, O;Galassi, D;Galdon-Quiroga, J;Galeani, S;Galperti, C;Gambrioli, M;Garavaglia, S;Garcia Herreros, S;Garcia Munoz, M;Gaudio, P;Gelfusa, M;Genoud, J;Gerasimov, S;Gil, L;Giroud, C;Giroud-Garampon, P;Gobbin, M;Golfinopoulos, T;Goodman, TP;Gorno, S;Grandin, M;Granucci, G;Graziano, F;Griener, M;Grzybicka, N;Guinchard, S;Hafner, R;Hakola, A;Halldestam, P;Ham, C;Hamel, Ph;Hamm, D;Heinrich, P;Heiss, C;Henderson, S;Hennequin, P;Hogge, J-P;Hojlund, R;Honore, C;Hoppe, M;Horacek, J;Huett, E;Innocente, P;Ivanov, P;Ivanov, V;Jackson, T;Jansen van Vuuren, A;Jardin, A;Jaspers, R;Jaulmes, F;Jensen, T;Jimenez Comez, M;Joffrin, E;Kabirov, D;Karpushov, AN;Kasilov, S;Kazakov, Y;Kerboua-Benlarbi, S;Khan, A;King, D;Kirjasuo, A;Kivits, EMM;Kobussen, S;Koenders, JTW;Kohli, P;Kolsen de Wit, J;Kominis, Y;Kong, M;Kool, B;Kovacic, J;Kropackova, D;Krutkin, O;Kumar, U;Kwiatkowski, R;La Matina, M;Labit, B;Lafay, A;Laporta, V;Lazic, N;Lee, K;Lengyel, F;Lim, K;Linehan, B;Listopad, A;Lobko, L;Lonigro, N;Lunt, T;Mackenbach, R;Macusova, E;Maget, P;Malec, S;Mancini, D;Mantica, P;Marchetto, C;Marchioni, S;Mariani, A;Marin, M;Marinoni, A;Markl, M;Martin, Y;Martinelli, L;Masillo, S;Masocco, R;Masson, V;Mattei, M;Mattogno, S;Mazon, D;Mazzi, S;Mele, A;Menkovski, V;Merle, A;Michi, A;Mirowski, R;Misdanitis, S;Mishra, R;Moiraf, D;Molina-Cabrera, PA;Molisani, S;Mombelli, F;Morgan, RI;Moro, A;Murari, A;Murray, K;Muscente, P;Muzio, I;Mykytchuk, D;Nakeva, Y;Napoli, F;Nielsen, AH;Nielsen, SK;Norman, T;Nowak, S;Nystrom, H;Ochoukov, R;Orduna-Martinez, A;Orlandi, L;Orrico, C;Orsitto, FP;Osawa, R;Osborne, N;Oyola, P;Paduaru, C;Pajares, A;Palade, DI;Pan, O;Panico, O;Papagiannis, P;Passoni, M;Pastore, F;Patel, A;Pau, A;Paz-Soldan, C;Pedersen, AC;Pedrini, M;Pelka, G;Perek, A;Peres Asnis, Y;Perillo, R;Pesamosca, F;Petersen, K;Pigatto, L;Piron, C;Piron, L;Pironti, A;Plyusnin, V;Podesta, M;Poels, Y;Pokol, GI;Poley, J;Pomarjanschi, L;Poradzinski, M;Porte, L;Possieri, C;Puentes del Pozo, F;Pueschel, MJ;Quadri, V;Rabinski, M;Ragona, R;Ratta, GA;Rea, C;Reimerdes, H;Reisner, M;Reux, C;Ricci, D;Ricci, P;Riedmiller, M;Rienacker, S;Rispoli, N;Rivero-Rodriguez, JF;Rizkallah, R;Rodriguez Gonzalez, A;Romano, F;Rossi, R;Rud, M;Sales de Oliveira, D;Salewski, M;Salmi, A;Sauter, O;S Schmidt, Bo;Schoonheere, N;Schutjes, K;Scotti, L;Senni, L;Senstius, MG;Setzu, S;Sharapov, SE;Sheikh, UA;Sias, G;Silva Fuglister, M;Silvagni, D;Simonetto, A;Simons, L;Singh, L;Singh, K;Sintre, P;Sipila, S;So, O;Sommariva, C;Sozzi, C;Spagnolo, S;Stagni, A;Stollberg, C;Subba, F;Sun, G;Sun, H;Svantner, J;Tala, T;Tamain, P;Tanaka, K;Tang, W;Tema Biwole, A;Tenaglia, A;Terranova, D;Testa, D;Thome, KE;Thrysoe, A;Tomes, M;Tonello, E;Topalova, MA;Tracey, B;Tsitrone, E;Tsui, CK;Tumbokon, J;Tunkl, M;Ugoletti, M;Valentini, A;Vallar, M;Van Berkel, M;van Leeuwen, L;Van Mulders, S;Van Parys, G;Van Rossem, M;Venturini, C;Verhaegh, K;Vermare, L;Vianello, N;Viezzer, E;Villard, L;Vincent, B;Vincent, C;Vincenzi, P;Vinklarek, J;Voitsekhovitch, I;Votta, L;Vu, NMT;Wang, A;Wang, C;Wang, Y;Wendler, N;Westerhof, E;Wiesen, S;Wijkamp, T;Winkel, M;Wuthrich, C;Wyss, I;Xiang, L;Xu, G;Yang, H;Zebrowski, J;Zestanakis, PA;Zhang, H;Zimmermann, CFB;Zuin, M;Zurita, M; 2026. Progress and innovations in the TCV tokamak research programme. Nuclear Fusion; 2026; Vol. 66; iss. 11
    LIRIAS4426229
    description

    Publisher: IOP Publishing Ltd
    Accepted
  • journal-article
    Vianello, N;Joffrin, E;Baruzzo, M;Hakola, A;Kappatou, A;Keeling, D;Labit, B;Tsitrone, E;Wischmeier, M;Adamek, J;Agostini, M;Albert, C;Albert Devasagayam, FCP;Alberti, G;Albrecht, F;Aleiferis, S;Alessi, E;Alhage, J;Allan, S;Alonzo, M;An, S;Anastasiou, G;Andersson-Sunden, E;Angioni, C;Antlitz, F;Antonenas, Y;Apruzzese, GM;Ariola, M;Artaud, JF;Arter, W;Ash, A;Asnis, Y;Asztalos, O;Aucone, L;Aumeunier, MH;Auriemma, F;Avanzato, C;Ayllon-Guerola, J;Aymerich, E;Baciero, A;Bairaktaris, F;Balazs, P;Balbinot, L;Balboa, I;Balestri, A;Bardsley, O;Battey, A;Bauer, T;Baumann, C;Bergmann, MG;Bergstroem, H;Bernard, E;Bernert, M;Biancalani, A;Bianchetti Morales, R;Bilato, R;Bilkova, P;Bin, W;Birkenmeier, G;Bisson, R;Blackmore, S;Blaise, F;Bobkov, V;Boboc, A;Bock, A;Bohm, P;Bolzonella, T;Bonalumi, L;Bonfiglio, D;Bonisolli, M;Borodin, D;Borodkina, I;Bosman, T;Bottereau, C;Bramucci, L;Brandstrom, B;Brezinsek, S;Brida, D;Brix, M;Brochard, F;Brown, B;Bruncrona, A;Brunetti, D;Bryant, J;Buermans, J;Bufferand, H;Burckhart, A;Cai, J;Caloud, J;Camera, G;Cani, F;Cannas, B;Cano Megias, P;Cappelli, M;Cardinali, A;Carli, S;Carnevale, D;Carpita, M;Carvalho, P;Casolari, A;Casson, F;Castaldo, C;Castro, R;Cathey, A;Causa, F;Cavalier, J;Cavedon, M;Cazabonne, J;Cecconello, M;Ceelen, L;Celora, A;Cerovsky, J;Challis, C;Chandra, R;Chapman-Oplopoiou, B;Chellai, O;Chen, X;Chernyshova, M;Chlum, J;Chmielewski, P;Chomiczewska, A;Cichocki, F;Cicioni, R;Cioffi, A;Ciraolo, G;Ciufo, S;Ciurlino, A;Civit, A;Clairet, F;Clod, A;Coda, S;Coelho, R;Coffey, I;Colas, L;Conroy, S;Contre, C;Conway, N;Coosemans, R;Cordaro, L;Cornelissen, M;Corre, Y;Costea, S;Courtois, X;Craciunescu, T;Croci, G;Crombe, K;Cruz Zabala, DJ;Cursi, F;Czarski, M;Czarski, T;D'Isa, FA;Dalla Rosa, M;Damiano, M;De Angeli, M;de la Cal, E;de la Luna, E;De Masi, G;De Piccoli, C;De Rycke, J;De Tommasi, G;Decker, J;Dejarnac, R;Dekeyser, W;Del Sarto, D;Delabie, E;Denis, J;Derks, G;Desgranges, C;Devlaminck, E;Devynck, P;di Grazia, LE;Di Troia, C;Dicorato, M;Diez, M;Dimitriou, V;Dimitrova, M;Dittmar, T;Dittrich, L;Grekov, D;Dreval, M;Dritselis, C;Dubbioso, S;Dubus, L;Ducker, R;Dudding, H;Dumont, R;Dumortier, P;Dunai, D;Dunne, M;Durif, A;Durr-Legoupil-Nicoud, G;Duval, B;Dux, R;Ebrahimi, F;Edes, L;Ekedahl, A;Elmore, S;Emanuelli, E;Ericsson, G;Eriksson, F;Eriksson, J;Eriksson, B;Ernst, D;Esposito, B;Fable, E;Faitsch, M;Fajardo, D;Fakhrayi Mofrad, N;Falchetto, GL;Fanni, A;Fedorczak, N;Ferreira, J;Ferron, N;Fevre, L;Fevrier, O;Ficker, O;Field, A;Figini, L;Figueiredo, A;Figueiredo, P;Fil, A;Fiorenza, F;Fiorucci, D;Firdaouss, M;Fischer, R;Fitzgerald, M;Flanagan, J;Fleury, L;Fonghetti, T;Fontdecaba Climent, JM;Forestier-Colleoni, P;Frank, A;Fransson, E;Frassinetti, L;Frattolillo, D;Frigione, D;Fugazza, SL;Futatani, S;Gabriellini, S;Galatola Teka, G;Galazka, K;Galdon-Quiroga, J;Galeani, S;Gallart, D;Gallo, A;Galperti, C;Gambrioli, M;Garavaglia, S;Garcia Herreros, S;Garcia Munoz, M;Gardarein, JL;Garzotti, L;Gaspar, J;Gatto, R;Gaudio, P;Gauthier, E;Gelfusa, M;Gerardin, J;Gerasimov, S;Gervasini, G;Geulin, E;Ghani, Z;Ghezzi, FM;Gil, L;Gillgren, A;Giovannozzi, E;Giroud, C;Gleiter, T;Gobbin, M;Goloborodko, V;Gonzalez-Martin, J;Gorini, G;Gossard, D;Grandin, M;Granucci, G;Grassler, G;Grenfell, G;Griener, M;Gromelski, W;Groth, M;Grover, O;Gruca, M;Grzybicka, N;Gude, A;Guillemaut, C;Guillevic, A;Guinchard, S;Guirlet, R;Gunn, J;Gyergyek, T;Hagg, L;Halldestam, P;Ham, C;Hamm, D;Harrison, J;Hasan-Toneva, E;Hawkes, N;Hegedus, S;Heinrich, P;Heiss, C;Henderson, S;Hennequin, P;Hernandez, C;Hillairet, J;Hjalmarsson, A;Hobirk, J;Hodille, E;Hojlund, R;Holzl, M;Hoppe, M;Horacek, J;Horsten, N;Houben, A;Hromadka, J;Hu, Q;Hua, J;Huang, Z;Huart, A;Hubbard, A;Huber, A;Huynh, P;Iafrati, M;Igochine, V;Imbeaux, F;Innocente, P;Isernia, N;Isliker, H;Ivanov, V;Ivanova, P;Ivanova Stanik, I;Jachmich, S;Jacquet, P;Jagielski, M;Jansen, L;Jansen van Vuuren, A;Jardin, A;Jarleblad, H;Jarvinen, A;Jaulmes, F;Jepu, I;Jimenez Comez, M;Jordan, D;Kabirov, D;Kachkanov, S;Kalis, J;Kallenbach, A;Karhunen, J;Karpushov, AN;Kaselouris, E;Kasilov, S;Kazakov, Y;Kazantzidis, P;Kim, HT;King, D;Kiptily, V;Kirjasuo, A;Kirk, A;Kirov, K;Kirschner, A;Kit, A;Kiviniemi, T;Knieps, A;Kobussen, S;Kocsis, G;Kogan, L;Kolsen de Wit, J;Kominis, Y;Komm, M;Kong, M;Kool, B;Korsholm, SB;Kos, D;Koubiti, M;Kovacic, J;Kovtun, Y;Kowalska-Strzeciwilk, E;Krieger, K;Kropackova, D;Krutkin, O;Kudashev, I;Kudlacek, O;Kuivasniemi, H;Kulyk, Y;Kumar, U;Kumpulainen, H;Kwiatkowski, R;La Matina, M;Ladygina, M;Lafay, A;Laguardia, L;Lainer, P;Laporta, V;Larsen, MR;Lawson, K;Lee, MYK;Lemoine, N;Lengyel, F;Lennholm, M;Leoni, C;Lerche, E;Leuthold, N;Li, X;Liang, YC;Liang, Y;Likonen, J;Lim, K;Litaudon, X;Litherland-Smith, E;Lo-Cascio, G;Loarer, T;Lobko, L;Lomanowski, B;Lombardo, J;Lonigro, N;Lorenzini, R;Lunt, T;Macdonald, J;Mackenbach, R;Macusova, E;Maenpaa, R;Maget, P;Maggi, C;Malec, S;Malinak, J;Malinowski, K;Manas, P;Mancini, D;Mantica, P;Mantsinen, M;Maraschek, M;Marcer, G;Marchetto, C;Marchioni, S;Mariani, A;Marin, M;Maris, D;Markl, M;Markovic, T;Marrelli, L;Martin, C;Masillo, S;Maslov, M;Masocco, R;Masson, V;Mattei, M;Mattogno, S;Matveev, D;Mayoral, ML;Mazon, D;Mazur, D;Mazzi, S;McKay, K;Andrew, A;Mele, A;Menkovski, V;Menmuir, S;Merchand, J;Merle, A;Mikszuta-Michalik, K;Milanesio, D;Milia, L;Miron, IG;Mirowski, R;Misdanitis, S;Mishra, R;Mitchell, J;Mitteau, R;Mitterauer, V;Moiraf, D;Moiseenko, V;Molina, P;Molisani, S;Mombelli, F;Monakhov, I;Monti, C;Montisci, A;Morales, J;Morbey, D;Moreau, A;Moreau, P;Morgan, R;Moritz, J;Moro, A;Moulton, D;Murari, A;Muraro, A;Murray, K;Myatra, O;Mykytchuk, D;Nabais, F;Nakeva, Y;Napoli, F;Nave, MF;Nelson, A;Nielsen, AH;Nielsen, SK;Niemela, A;Nocente, M;Nouailletas, R;Nowak, S;Nystrom, H;O'Mullane, M;Ochoukov, R;Olasz, S;Olde, C;Oliver, J;Ongena, J;Ordonez Jimenez, JM;Orduna Martinez, A;Orlandi, L;Orrico, C;Orsitto, FP;Osawa, R;Osipov, A;Otin, R;Palacios Roman, JJ;Palade, D;Pan, O;Panadero, N;Panera Alvarez, A;Papagiannis, P;Papp, G;Parail, V;Parrott, A;Paschalidis, K;Passoni, M;Pastore, F;Patel, B;Patel, A;Patel, AH;Pau, A;Pawelec, E;Pedrini, M;Pelka, G;Peluso, E;Perek, A;Perez Gonzalez, J;Perez Von Thun, C;Pesamosca, F;Peterka, M;Petersen, K;Petersson, P;Pigatto, L;Piron, L;Piron, C;Pironti, A;Pisano, F;Plyusnin, V;Podesta, M;Podolnik, A;Poels, Y;Pokol, G;Poley, J;Pomarjanschi, LM;Poradzinski, M;Porte, L;Possieri, C;Predebon, I;Pucella, G;Puentes del Pozo, F;Pueschel, MJ;Puglia, P;Putterich, T;Quadri, V;Rabinski, M;Ragona, R;Rasinski, M;Rasmussen, J;Ratta, G;Ratynskaia, S;Ravensbergen, T;Rebai, M;Rees, D;Refy, D;Regine, M;Reimerdes, H;Reisner, M;Reman, B;Ren, P;Reux, C;Reyner-Vinolas, A;Ricci, D;Richou, M;Rienacker, S;Rigamonti, D;Rigollet, F;Rikala, VP;Rimini, F;Rispoli, N;Rivals, N;Rodriguez Gonzalez, A;Rivero-Rodriguez, JF;Rizzi, T;Roach, C;Robaldo, MM;Rode, S;Rodrigues, P;Rohde, V;Romazanov, J;Rossi, R;Rubino, G;Rueda-Rueda, J;Ruffini, F;Ryan, P;Ryan, D;Rzadkiewicz, J;Saarelma, S;Saari, S;Sabot, R;Sackers, M;Sales de Oliveira, D;Salewski, M;Salmi, A;Salvia, C;Sanchis, L;Santos, J;Sartorello, S;Sauter, O;Scannell, R;Schatzlmayr, J;Schiesko, L;Schmidt, BS;Schneider, PA;Schoonheere, N;Schutjes, K;Scotti, L;Scotti, F;Seidl, J;Senni, L;Sergienko, G;Setzu, S;Sgrelli, D;Sharapov, S;Sharma, R;Sheikh, U;Sias, G;Sieglin, B;Silburn, S;Silva, C;Silva, A;Silvagni, D;Simons, L;Simpson, J;Singh, L;Sipila, S;Skyllas, MM;Solano, ER;Sos, M;Sozzi, C;Spagnolo, S;Srinivasan, C;Stagni, A;Stancar, Z;Stankunas, G;Stieglitz, D;Stobbs, J;Strand, P;Subba, F;Sun, H;Sun, GY;Suttrop, W;Svantner, JP;Svoboda, J;Svorc, D;Szepesi, G;Szepesi, T;Taccogna, F;Takacs, R;Tala, T;Tamain, P;Tan, M;Tang, W;Tardocchi, M;Taylor, D;Telesca, G;Tenaglia, A;Terranova, D;Testa, D;Theiler, C;Tholerus, E;Thomas, B;Thrysoe, A;Tichit, Q;Titarenko, A;Tolias, P;Tomasina, E;Tomes, M;Tonel, A;Tonello, E;Tookey, A;Tosto, B;Trier, E;Tumbokon, JW;Tunkl, M;Uccello, A;Ugoletti, M;Ulbl, P;Urbanczyk, G;Valentini, A;Valovic, M;van Berkel, M;Van Eester, D;Van Parys, G;van Rossem, M;Vanovac, B;Varadarajan, HP;Vartanian, S;Vavrik, M;Vaz, M;Vega, J;Velarde Gallardo, L;Venturini, C;Veranda, M;Verdier, T;Verdoolaege, G;Verhaegh, K;Vermare, L;Vesa, A;Vicente, J;Viezzer, E;Vignitchouk, L;Villone, F;Vincent, C;Vincent, B;Vincenzi, P;Vinklarek, J;Virtanen, P;Voitsekhovitch, I;Votta, L;Vulcano, M;Vuoriheimo, T;Wang, E;Wang, Y;Wang, C;Wauters, T;Weisen, H;Wendler, N;Widdowson, A;Wiesen, S;Wiesenberger, M;Wijkamp, T;Willensdorfer, M;Winkel, M;Wojenski, A;Wolfrum, E;Wu, H;Wyss, I;Xia, Q;Xiang, L;Xie, P;Xu, S;Yadykin, D;Yan, X;Yang, Y;Yang, H;Ye, K;Zagorski, R;Zanca, P;Zastrow, KD;Zayachuk, Y;Zebrowski, J;Zenz, P;Zerbini, M;Zestanakis, P;Zhang, H;Zhang, Y;Zholobenko, W;Zimmermann, B;Zito, A;Zlobinski, M;Zotta, VK;Zuin, M;Zurita, M; 2026. Results from the last DD and DT JET campaigns in the framework of the EUROfusion Tokamak Exploitation Work Package activity. Nuclear Fusion; 2026; Vol. 66; iss. 11
    LIRIAS4429162
    description

    Publisher: IOP Publishing Ltd
    Accepted
  • journal-article
    Abbasi, R;Ackermann, M;Adams, J;Agarwalla, SK;Aguilar, JA;Ahlers, M;Alameddine, JM;Amin, NM;Andeen, K;Arguelles, C;Ashida, Y;Athanasiadou, S;Axani, SN;Babu, R;Bai, X;Balagopal, A;Baricevic, M;Barwick, SW;Bash, S;Basu, V;Bay, R;Beatty, JJ;Tjus, J Becker;Behrens, P;Beise, J;Bellenghi, C;Benkel, B;BenZvi, S;Berley, D;Bernardini, E;Besson, DZ;Blaufuss, E;Bloom, L;Blot, S;Bontempo, F;Motzkin, JY Book;Meneguolo, C Boscolo;Boser, S;Botner, O;Bottcher, J;Braun, J;Brinson, B;Brisson-Tsavoussis, Z;Burley, RT;Butterfield, D;Campana, MA;Carloni, K;Carpio, J;Chattopadhyay, S;Chau, N;Chen, Z;Chirkin, D;Clark, BA;Coleman, A;Coleman, P;Collin, GH;Connolly, A;Conrad, JM;Corley, R;Cowen, DF;De Clercq, C;DeLaunay, JJ;Delgado, D;Delmeulle, T;Deng, S;Desai, A;Desiati, P;de Vries, KD;De Wasseige, G;DeYoung, T;Diaz-Velez, JC;Diaz, A;DiKerby, S;Dittmer, M;Domi, A;Draper, L;Dueser, L;Dujmovic, H;Durnford, D;Dutta, K;DuVernois, MA;Ehrhardt, T;Eidenschink, L;Eimer, A;Eller, P;Ellinger, E;Elsasser, D;Engel, R;Erpenbeck, H;Esmail, W;Evans, J;Evenson, PA;Fan, KL;Fang, K;Farrag, K;Fazely, AR;Fedynitch, A;Feigl, N;Finley, C;Fischer, L;Fox, D;Franckowiak, A;Fukami, S;Furst, P;Gallagher, J;Ganster, E;Garcia, A;Garcia, M;Garg, G;Genton, E;Gerhardt, L;Ghadimi, A;Glaser, C;Glusenkamp, T;Gonzalez, JG;Goswami, S;Granados, A;Grant, D;Gray, SJ;Griffin, S;Griswold, S;Groth, KM;Guevel, D;Gunther, C;Gutjahr, P;Ha, C;Haack, C;Hallgren, A;Halve, L;Halzen, F;Hamacher, L;Minh, M Ha;Handt, M;Hanson, K;Hardin, J;Harnisch, AA;Hatch, P;Haungs, A;Haussler, J;Helbing, K;Hellrung, J;Hennig, L;Heuermann, L;Hewett, R;Heyer, N;Hickford, S;Hidvegi, A;Hill, C;Hill, GC;Hmaid, R;Hoffman, KD;Hori, S;Hoshina, K;Hostert, M;Hou, W;Huber, T;Hultqvist, K;Hussain, R;Hymon, K;Ishihara, A;Iwakiri, W;Jacquart, M;Jain, S;Janik, O;Jeong, M;Jin, M;Jones, BJP;Kamp, N;Kang, D;Kang, X;Kappes, A;Kardum, L;Karg, T;Karl, M;Karle, A;Katil, A;Kauer, M;Kelley, JL;Khanal, M;Zathul, A Khatee;Kheirandish, A;Kimku, H;Kiryluk, J;Klein, C;Klein, SR;Kobayashi, Y;Kochocki, A;Koirala, R;Kolanoski, H;Kontrimas, T;Kopke, L;Kopper, C;Koskinen, DJ;Koundal, P;Kowalski, M;Kozynets, T;Krieger, N;Krishnamoorthi, J;Krishnan, T;Kruiswijk, K;Krupczak, E;Kumar, A;Kun, E;Kurahashi, N;Lad, N;Gualda, C Lagunas;Arnaud, L Lallement;Lamoureux, M;Larson, MJ;Lauber, F;Lazar, JP;DeHolton, K Leonard;Leszczynska, A;Liao, J;Liu, YT;Liubarska, M;Love, C;Lu, L;Lucarelli, F;Luszczak, W;Lyu, Y;Madsen, J;Magnus, E;Mahn, KBM;Makino, Y;Manao, E;Mancina, S;Mand, A;Sainte, W Marie;Maris, IC;Marka, S;Marka, Z;Marten, L;Martinez-Soler, I;Maruyama, R;Mayhew, F;McNally, F;Mead, JV;Meagher, K;Mechbal, S;Medina, A;Meier, M;Merckx, Y;Merten, L;Mitchell, J;Molchany, L;Montaruli, T;Moore, RW;Morii, Y;Morse, R;Mosbrugger, A;Moulai, M;Mousadi, D;Mukherjee, T;Naab, R;Nakos, M;Naumann, U;Necker, J;Neste, L;Neumann, M;Niederhausen, H;Nisa, MU;Noda, K;Noell, A;Novikov, A;Pollmann, A Obertacke;O'Dell, V;Olivas, A;Orsoe, R;Osborn, J;O'Sullivan, E;Palusova, V;Pandya, H;Parenti, A;Park, N;Parrish, V;Paudel, EN;Paul, L;de los Heros, C Perez;Pernice, T;Peterson, J;Pizzuto, A;Plum, M;Ponten, A;Poojyam, V;Popovych, Y;Rodriguez, M Prado;Pries, B;Procter-Murphy, R;Przybylski, GT;Pyras, L;Raab, C;Rack-Helleis, J;Rad, N;Ravn, M;Rawlins, K;Rechav, Z;Rehman, A;Reistroffer, I;Resconi, E;Reusch, S;Rho, CD;Rhode, W;Riedel, B;Rifaie, A;Roberts, EJ;Robertson, S;Rongen, M;Rosted, A;Rott, C;Ruhe, T;Ruohan, L;Safa, I;Saffer, J;Salazar-Gallegos, D;Sampathkumar, P;Sandrock, A;Sanger-Johnson, G;Santander, M;Sarkar, S;Savelberg, J;Savina, P;Schaile, P;Schaufel, M;Schieler, H;Schindler, S;Schlickmann, L;Schneider, A;Schluter, B;Schluter, F;Schmeisser, N;Schmidt, T;Schroder, FG;Schumacher, L;Schwirn, S;Sclafani, S;Seckel, D;Seen, L;Seikh, M;Seunarine, S;Myhr, PA Sevle;Shah, R;Shefali, S;Shimizu, N;Silva, M;Skrzypek, B;Snihur, R;Soedingrekso, J;Sogaard, A;Soldin, D;Soldin, P;Sommani, G;Spannfellner, C;Spiczak, GM;Spiering, C;Stachurska, J;Stamatikos, M;Stanev, T;Stezelberger, T;Sturwald, T;Stuttard, T;Sullivan, GW;Taboada, I;Ter-Antonyan, S;Terliuk, A;Thakuri, A;Thiesmeyer, M;Thompson, WG;Thwaites, J;Tilav, S;Tollefson, K;Toscano, S;Tosi, D;Trettin, A;Elorrieta, MA Unland;Upadhyay, AK;Upshaw, K;Vaidyanathan, A;Valtonen-Mattila, N;Vandenbroucke, J;Van Eeden, T;van Eijndhoven, N;van Santen, J;Vara, J;Varsi, F;Veitch-Michaelis, J;Venugopal, M;Vereecken, M;Carrasco, S Vergara;Verpoest, S;Veske, D;Vijai, A;Villarreal, J;Walck, C;Wandkowsky, N;Wang, A;Warrick, E;Weaver, C;Weigel, P;Weindl, A;Wen, AY;Wendt, C;Werthebach, J;Weyrauch, M;Whitehorn, N;Wiebusch, CH;Williams, DR;Witthaus, L;Wolf, M;Wrede, G;Xu, XW;Yanez, JP;Yildizci, E;Yoshida, S;Young, R;Yu, F;Yu, S;Yuan, T;Zegarelli, A;Zhang, S;Zhang, Z;Zhelnin, P;Zilberman, P;Zimmerman, M; 2026. GollumFit: An icecube open-source framework for binned-likelihood neutrino telescope analyses. Computer Physics Communications; 2026; Vol. 326
    LIRIAS4427133
    description

    Publisher: Elsevier
    Accepted
  • journal-article
    Deleenheer, B;Carlin, S;Chan, N;Coppens, M;Corcos, O;Cuerda, C;Douketis, J;Jeppesen, PB;Joly, F;Lal, S;Lamprecht, G;Meade, U;Mundi, M;Pironi, L;Szczepanek, K;Vanassche, T;Van Gossum, A;Wanten, G;Van der Linden, L;Vanuytsel, T; 2026. Long-term antithrombotic therapy in patients with short bowel syndrome: A European Society for Clinical Nutrition and Metabolism (ESPEN) position paper. Clinical Nutrition; 2026; Vol. 64
    LIRIAS4438425
    description

    Publisher: Elsevier
    Published
  • journal-article
    Luyckx, L;Myllykangas, M;Kinnunen, J;Lukashevich, S;Salumets, A;Velthut-Meikas, A;Rooda, I;Izzi, V;Arffman, RK;Saarela, U;Piltonen, TT; 2026. The impact of menstrual cycle phase and BMI on mitochondrial dysfunction in PMOS endometrium. Human Reproduction; 2026
    LIRIAS4435518
    description
    STUDY QUESTION: Does the endometrium of oligo-ovulatory women with polyendocrine metabolic ovarian syndrome (PMOS) exhibit menstrual cycle phase-specific transcriptomic alterations compared to women without PMOS? SUMMARY ANSWER: Compared to healthy controls, women with PMOS exhibit endometrial transcriptomic dysregulations which are menstrual cycle phase-specific and, most notably, related to mitochondrial function. WHAT IS KNOWN ALREADY: Infertility and gestational dysfunction in women with PMOS are increasingly attributed to endometrial abnormalities, yet the underlying mechanisms behind PMOS-related endometrial dysfunction remain unclear. Previous studies have focused on anovulatory phenotypes, resulting in a poor understanding of cycle phase-specific defects in the endometria of women with PMOS. STUDY DESIGN, SIZE, DURATION: Endometrial biopsies were obtained from oligo-ovulatory women with PMOS and healthy controls at four distinct menstrual cycle phases (proliferative, early-, mid-, and late-secretory phases) and subjected to RNA sequencing. Parallel in vitro experiments were conducted using cultured endometrial stromal cells (ESCs) and epithelial organoids (EEOs) derived from an additional endometrial sample cohort. PARTICIPANTS/MATERIALS, SETTING, METHODS: RNA sequencing was performed on biopsies from 78 (oligo-)ovulatory women, age- and BMI-matched between PMOS (n = 39) and control (n = 39) groups. Phase-specific transcriptomic profiles and pathway enrichment analyses were performed. For functional assays, endometrial cells were isolated from four PMOS and four control donors per BMI group (lean: < 25 kg/m2; obese: ≥30 kg/m2). Mitochondrial function, including respiration, ATP and reactive oxygen species production, and membrane potential, was assessed in both cell types before and after hormonal exposure. MAIN RESULTS AND THE ROLE OF CHANCE: Endometrial transcriptomes clustered primarily by cycle phase; however, PMOS-specific dysregulation was observed related to extracellular matrix organization, estrogen receptor (ESR) signaling, ion transport, and mitochondrial respiratory function. Gene trajectory analyses revealed phase-specific alterations in progesterone-, insulin signaling-, and mitochondria-related gene expression during the early-secretory phase, and epithelial function during the mid-secretory phase. Functionally, decidualized ESCs from obese PMOS women displayed reduced mitochondrial respiration, whereas EEOs from lean PMOS patients exhibited increased mitochondrial activity. LARGE SCALE DATA: Sequencing data are available from the corresponding author upon request. LIMITATIONS, REASONS FOR CAUTION: Women with PMOS were oligo-ovulatory while controls exhibited regular cycles. The sample size for in vitro studies was modest, warranting validation in larger cohorts. Additionally, the use of bulk RNA sequencing may obscure cell-type-specific transcriptomic signatures, emphasizing the need for future single-cell approaches to dissect cellular heterogeneity in PMOS endometrium. WIDER IMPLICATIONS OF THE FINDINGS: This study uncovers dynamic, cycle phase-dependent molecular and bioenergetic alterations in the endometrium of oligo-ovulatory women with PMOS. Mitochondrial dysfunction, particularly during the implantation window, emerges as a key pathological feature. The observed BMI-dependent divergence in mitochondrial function suggests that personalized therapeutic strategies may be necessary to improve reproductive outcomes in women with PMOS. FUNDING: Funded by the Jusélius Foundation, Novo Nordisk Foundation, Research Council of Finland, and the Horizon 2020 Marie-Curie MATER Innovative Training Network (all to T.T.P.), with additional support from the University of Oulu Scholarship Foundation (L.L.), the Estonian Research Council (E.V.M. and I.R.), and the Estonian Research Council grant no. PRG1076, Swedish Research Council grant no. 2024-02530, Novo Nordisk Foundation grant no. NNF24OC0092384 and Horizon Europe grant NESTOR, grant no. 101120075 (A.S.). DISCLOSURES: The authors declare no competing interests.
    Publisher: Oxford University Press (OUP)
    Published online
  • journal-article
    Diab, Emtinan;Thome, Nicola U;Elsayed, Somayah S;Raaijmakers, Jos M;van Wezel, Gilles P; 2026. Chemical dialogues at the crossroads of host-bacteria interactions.. Trends Microbiol; 2026; Vol. 34; iss. 8; pp. 892 - 905
    LIRIAS4417338
    description
    Microbiomes are now recognised as the second genome of eukaryotes, providing diverse life-support functions for their hosts. The impact of microbiome members on the growth and health of their hosts is determined by chemical cues from the host that modulate microbial physiology, virulence, and the biosynthesis of specialised metabolites. In this review, we provide a cross-kingdom comparison of the role of human and plant molecules in regulating bacterial gene expression. We highlight specific feedback loops and discuss common mechanisms of bidirectional cueing in human- and plant-associated bacteria. Despite the different taxonomies of human- and plant-associated bacteria, we find striking functional similarities in the chemical dialogues at the crossroads of host-bacteria interactions.

    Published
  • journal-article
    Langenaeken, Tom;Vanglabeke, Lennart;Van Hecke, Manon;De Meester, Pieter;Verbelen, Tom;Verbrugghe, Peter;Rega, Filip;Lorentz, Christina U;Tucker, Erik I;Meuris, Bart; 2026. Factor XI inhibition with gruticibart prevents mechanical valve thrombosis in a porcine pulmonary model.. Blood Vessel Thromb Hemost; 2026; Vol. 3; iss. 3; pp. 100168 - ...
    LIRIAS4427071
    description
    Mechanical heart valves have excellent lifelong durability but require lifelong anticoagulation, traditionally with vitamin K antagonists, which increase bleeding risk and require monitoring. Factor XI (FXI) inhibitors may provide safer anticoagulation by targeting the intrinsic pathway while preserving hemostasis. This study evaluated whether FXI inhibition with the A2-domain-specific monoclonal antibody, gruticibart (AB023), could prevent thrombosis of mechanical valves after implantation in the pulmonary position of pigs, without causing bleeding or thromboembolic complications. Six juvenile pigs underwent pulmonary valve replacement with 21-mm On-X mechanical valves; 3 pigs received gruticibart, and 3 received no treatment. Animals were followed up for 3 months or until valve failure. Valve motion was assessed with serial fluoroscopy and cardiac ultrasonography. At termination, valves and lungs were examined macroscopically and histologically. Activated partial thromboplastin time (aPTT) was monitored to confirm the anticoagulant effect. Gruticibart more than doubled the baseline aPTT and maintained a stable prolongation to ∼40 seconds. All gruticibart-treated valves remained fully functional throughout the study, with unrestricted leaflet motion and normal gradients. No thrombus, hinge obstruction, or pulmonary emboli were identified at explantation. In contrast, all control animals developed severe valve thrombosis requiring early termination at 16, 24, and 49 days. No bleeding or thromboembolic events occurred in either group. Factor XI inhibition with gruticibart fully prevented mechanical valve thrombosis in this validated porcine model. Biweekly dosing produced stable anticoagulation without bleeding. These findings support FXI inhibition as a promising alternative to vitamin K antagonists for mechanical valve anticoagulation and justify larger, longer-term studies.

    Published online
  • preprint
    Levi, Hagai;Wang, Qin;Bolla, Manjeet K;Dennis, Joe;Andrulis, Irene L;Antonenkova, Natalia;Au, Chun Hang;Augustinsson, Annelie;Beane Freeman, Laura E;Behrens, Sabine;Bermisheva, Marina;Bodelon, Clara;Bogdanova, Natalia V;Bojesen, Stig E;Brenner, Hermann;Brock, Ian W;Brüning, Thomas;Byers, Helen;Camp, Nicola J;Castelao, Jose E;Choi, Ji-Yeob;Chung, Wendy K;NBCS Collaborators, ;Colonna, Sarah V;Couch, Fergus J;Czene, Kamila;Daly, Mary B;Devilee, Peter;Dörk, Thilo;Eliassen, A Heather;Eriksson, Mikael;Evans, D Gareth;Fasching, Peter A;Faw, Kierstin;Gago-Dominguez, Manuela;García-Closas, Montserrat;Haiman, Christopher A;Hamann, Ute;Hartman, Mikael;Ho, Vikki;Ho, Peh Joo;Hooning, Maartje J;Hoppe, Reiner;Howell, Sacha J;ABCTB Investigators, ;SGBCC Investigators, ;Ito, Hidemi;Iwasaki, Motoki;Jakubowska, Anna;Jernström, Helena;Joseph, Vijai;Kaaks, Rudolf;Kang, Daehee;Khusnutdinova, Elza K;Kiprijanovska, Sanja;Koutros, Stella;Kristensen, Vessela N;Kurian, Allison W;Kwong, Ava;Lambrechts, Diether;Larson, Nicole L;Marchand, Loic Le;Li, Shuai;Li, Jingmei;Lophatananon, Artitaya;Mannermaa, Arto;Matsuo, Keitaro;Maxwell, Whitney;Muir, Kenneth;Nevelsteen, Ines;Obi, Nadia;O'Brien, Katie M;Offit, Kenneth;Ottewell, Penelope D;Patel, Alpa V;Peterlongo, Paolo;Plaseska-Karanfilska, Dijana;Prajzendanc, Karolina;Radice, Paolo;Ramachandran, Dhanya;Rashid, Muhammad U;Romero, Atocha;Saloustros, Emmanouil;Sandler, Dale P;Schöttker, Ben;Simard, Jacques;Southey, Melissa C;Stone, Jennifer;Sugier, Pierre-Emmanuel;Taylor, Jack A;Teras, Lauren R;Truong, Thérèse;Weinberg, Clarice R;Yadav, Siddhartha;Yamaji, Taiki;Zheng, Wei;Dunning, Alison M;Mavaddat, Nasim;Easton, Douglas F;Michailidou, Kyriaki;Elkon, Ran;Shamir, Ron; 2026. PRANA: A Deep Learning Method for Adapting Polygenic Risk Scores to Diverse Ethnic Groups. medRxiv; 2026
    LIRIAS4434356
    description
    Polygenic risk scores (PRSs), which quantify inherited susceptibility to complex traits and diseases, have emerged as valuable tools for risk stratification and precision medicine. Despite their promise, PRS developed on European cohorts often demonstrate substantially reduced predictive accuracy in non-European populations, due to differences in genetic architecture. The disproportionate representation of European ancestry cohorts in genome-wide association studies (GWAS) leads to inequitable deployment of PRS technologies across diverse populations. Here, we introduce PRANA (Polygenic Risk Adaptation via Neural-network Architecture), a deep learning framework that adapts an existing PRS developed on one population to other ancestries. Unlike methods that require large-scale GWAS in the target population, PRANA leverages pre-trained PRS models derived from European cohorts and adapts them using modestly sized cohorts from the target population. We evaluated PRANA on seven complex traits in South Asian, East Asian and Ashkenazi Jewish populations, as well as in selected smaller East Asian subpopulations where the scarcity of training data poses a particular challenge. PRANA mostly improved predictive performance of the baseline PRS models by 5%-20% in terms of effect size (β) and Nagelkerke's R2, and, in most cases, outperformed existing cross-ancestry multi-PRS approaches. These results highlight PRANA as a scalable and practical strategy to reduce disparities in genomic risk prediction and advance the equitable application of PRS in diverse populations.

  • journal-article
    Abac, AG;Abouelfettouh, I;Acernese, F;Ackley, K;Adamcewicz, C;Adhicary, S;Adhikari, D;Adhikari, N;Adhikari, RX;Adkins, VK;Afroz, S;Agarwal, D;Agathos, M;Abchouyeh, M Aghaei;Aguiar, OD;Ahmadzadeh, S;Aiello, L;Ain, A;Ajith, P;Akutsu, T;Albanesi, S;Alfaidi, RA;Al-Jodah, A;Allene, C;Allocca, A;Al-Shammari, S;Altin, PA;Alvarez-Lopez, S;Amarasinghe, O;Amato, A;Amra, C;Ananyeva, A;Anderson, SB;Anderson, WG;Andia, M;Ando, M;Andrade, T;Andres-Carcasona, M;Andric, T;Anglin, J;Ansoldi, S;Antelis, JM;Antier, S;Aoumi, M;Appavuravther, EZ;Appert, S;Apple, SK;Arai, K;Araya, A;Araya, MC;Sedda, M Arca;Areeda, JS;Argianas, L;Aritomi, N;Armato, F;Armstrong, S;Arnaud, N;Arogeti, M;Aronson, SM;Arun, KG;Ashton, G;Aso, Y;Assiduo, M;Melo, S Assis de Souza;Aston, SM;Astone, P;Attadio, F;Aubin, F;AultONeal, K;Avallone, G;Babak, S;Badaracco, F;Badger, C;Bae, S;Bagnasco, S;Bagui, E;Baiotti, L;Bajpai, R;Baka, T;Baker, T;Ball, M;Ballardin, G;Ballmer, SW;Banagiri, S;Banerjee, B;Bankar, D;Baptiste, TM;Baral, P;Barayoga, JC;Barish, BC;Barker, D;Barman, N;Barneo, P;Barone, F;Barr, B;Barsotti, L;Barsuglia, M;Barta, D;Bartoletti, AM;Barton, MA;Bartos, I;Basak, S;Basalaev, A;Bassiri, R;Basti, A;Bates, DE;Bawaj, M;Baxi, P;Bayley, JC;Baylor, AC;Baynard, PA;Bazzan, M;Bedakihale, VM;Beirnaert, F;Bejger, M;Belardinelli, D;Bell, AS;Bellie, DS;Bellizzi, L;Beltran-Martinez, D;Benoit, W;Bentara, I;Bentley, JD;Ben Yaala, M;Bera, S;Bergamin, F;Berger, BK;Bernuzzi, S;Beroiz, M;Berry, CPL;Bersanetti, D;Bertolini, A;Betzwieser, J;Beveridge, D;Bevilacqua, G;Bevins, N;Bhandare, R;Bhatt, R;Bhattacharjee, D;Bhaumik, S;Bhowmick, S;Biancalana, V;Bianchi, A;Bilenko, IA;Billingsley, G;Binetti, A;Bini, S;Binu, C;Birnholtz, O;Biscoveanu, S;Bisht, A;Bitossi, M;Bizouard, M-A;Blaber, S;Blackburn, JK;Blagg, LA;Blair, CD;Blair, DG;Bobba, F;Bode, N;Boileau, G;Boldrini, M;Bolingbroke, GN;Bolliand, A;Bonavena, LD;Bondarescu, R;Bondu, F;Bonilla, E;Bonilla, MS;Bonino, A;Bonnand, R;Booker, P;Borchers, A;Borhanian, S;Boschi, V;Bose, S;Bossilkov, V;Boudon, A;Bozzi, A;Bradaschia, C;Brady, PR;Branch, A;Branchesi, M;Braun, I;Briant, T;Brillet, A;Brinkmann, M;Brockill, P;Brockmueller, E;Brooks, AF;Brown, BC;Brown, DD;Brozzetti, ML;Brunett, S;Bruno, G;Bruntz, R;Bryant, J;Bu, Y;Bucci, F;Buchanan, J;Bulashenko, O;Bulik, T;Bulten, HJ;Buonanno, A;Burtnyk, K;Buscicchio, R;Buskulic, D;Buy, C;Byer, RL;Davies, GS Cabourn;Cabras, G;Cabrita, R;Caceres-Barbosa, V;Cadonati, L;Cagnoli, G;Cahillane, C;Calafat, A;Calderon Bustillo, J;Callister, TA;Calloni, E;Canepa, M;Santoro, G Caneva;Cannon, KC;Cao, H;Capistran, LA;Capocasa, E;Capote, E;Capurri, G;Carapella, G;Carbognani, F;Carlassara, M;Carlin, JB;Carlson, TK;Carney, MF;Carpinelli, M;Carrillo, G;Carter, JJ;Carullo, G;Diaz, J Casanueva;Casentini, C;Castro-Lucas, SY;Caudill, S;Cavaglia, M;Cavalieri, R;Cella, G;Cerda-Duran, P;Cesarini, E;Chaibi, W;Chakraborty, P;Chakraborty, S;Subrahmanya, S Chalathadka;Chan, JCL;Chan, M;Chang, R-J;Chao, S;Charlton, EL;Charlton, P;Chassande-Mottin, E;Chatterjee, C;Chatterjee, Debarati;Chatterjee, Deep;Chattopadhyay, D;Chaturvedi, M;Chaty, S;Chatziioannou, K;Checchia, C;Chen, A;Chen, AH-Y;Chen, D;Chen, H;Chen, HY;Chen, S;Chen, Y;Chen, Yanbei;Chen, Yitian;Cheng, HP;Chessa, P;Cheung, HT;Cheung, SY;Chiadini, F;Chiarini, G;Chierici, R;Chincarini, A;Chiofalo, ML;Chiummo, A;Chou, C;Choudhary, S;Christensen, N;Chua, SSY;Chugh, P;Ciani, G;Ciecielag, P;Cieslar, M;Cifaldi, M;Ciolfi, R;Clara, F;Clark, JA;Clarke, J;Clarke, TA;Clearwater, P;Clesse, S;Clyne, SM;Coccia, E;Codazzo, E;Cohadon, P-F;Colace, S;Colangeli, E;Colleoni, M;Collette, CG;Collins, J;Colloms, S;Colombo, A;Compton, CM;Connolly, G;Conti, L;Corbitt, TR;Cordero-Carrion, I;Corezzi, S;Cornish, NJ;Corsi, A;Cortese, S;Cottingham, R;Coughlin, MW;Couineaux, A;Coulon, J-P;Coupechoux, J-F;Couvares, P;Coward, DM;Coyne, R;Craig, K;Creighton, JDE;Creighton, TD;Cremonese, P;Criswell, AW;Crook, S;Crouch, R;Csizmazia, J;Cudell, JR;Cullen, TJ;Cumming, A;Cuoco, E;Cusinato, M;Dabadie, P;Da Conceicao, LV;Dal Canton, T;Dall'Osso, S;Dal Pra, S;Dalya, G;D'Angelo, B;Danilishin, S;D'Antonio, S;Danzmann, K;Darroch, KE;Dartez, LP;Dasgupta, A;Datta, S;Dattilo, V;Daumas, A;Davari, N;Dave, I;Davenport, A;Davier, M;Davies, TF;Davis, D;Davis, L;Davis, MC;Davis, P;Dax, M;De Bolle, J;Deenadayalan, M;Degallaix, J;De Laurentis, M;Deleglise, S;De Lillo, F;Dell'Aquila, D;Della Valle, F;Del Pozzo, W;De Marco, F;Demasi, G;De Matteis, F;D'Emilio, V;Demos, N;Dent, T;Depasse, A;DePergola, N;De Pietri, R;De Rosa, R;De Rossi, C;Desai, M;DeSalvo, R;DeSimone, A;De Simone, R;Dhani, A;Diab, R;Diaz, MC;Di Cesare, M;Dideron, G;Didio, NA;Dietrich, T;Di Fiore, L;Di Fronzo, C;Di Giovanni, M;Di Girolamo, T;Diksha, D;Di Michele, A;Ding, J;Di Pace, S;Di Palma, I;Di Renzo, F;Divyajyoti, ;Dmitriev, A;Doctor, Z;Doerksen, N;Dohmen, E;Dominguez, D;D'Onofrio, L;Donovan, F;Dooley, KL;Dooney, T;Doravari, S;Dorosh, O;Drago, M;Driggers, JC;Ducoin, J-G;Dunn, L;Dupletsa, U;D'Urso, D;Duval, H;Dwyer, SE;Eassa, C;Ebersold, M;Eckhardt, T;Eddolls, G;Edelman, B;Edo, TB;Edy, O;Effler, A;Eichholz, J;Einsle, H;Eisenmann, M;Eisenstein, RA;Ejlli, A;Emma, M;Endo, K;Enficiaud, R;Engl, AJ;Errico, L;Espinosa, R;Esposito, M;Essick, RC;Estelles, H;Etzel, T;Evans, M;Evstafyeva, T;Ewing, BE;Ezquiaga, JM;Fabrizi, F;Faedi, F;Fafone, V;Fairhurst, S;Farah, AM;Farr, B;Farr, WM;Favaro, G;Favata, M;Fays, M;Fazio, M;Feicht, J;Fejer, MM;Felicetti, R;Fenyvesi, E;Ferguson, DL;Fernandes, T;Fernando, A;Fernando, D;Ferraiuolo, S;Ferrante, I;Ferreira, TA;Fidecaro, F;Figura, P;Fiori, A;Fiori, I;Fishbach, M;Fisher, RP;Fittipaldi, R;Fiumara, V;Flaminio, R;Fleischer, SM;Fleming, LS;Floden, E;Fong, H;Font, JA;Foo, C;Fornal, B;Forsyth, PWF;Franceschetti, K;Franchini, N;Frasca, S;Frasconi, F;Mascioli, A Frattale;Frei, Z;Freise, A;Freitas, O;Frey, R;Frischhertz, W;Fritschel, P;Frolov, VV;Fronze, GG;Fuentes-Garcia, M;Fujii, S;Fujimori, T;Fulda, P;Fyffe, M;Gadre, B;Gair, JR;Galaudage, S;Galdi, V;Gallagher, H;Gallego, B;Gamba, R;Gamboa, A;Ganapathy, D;Ganguly, A;Garaventa, B;Garcia-Bellido, J;Nunez, C Garcia;Garcia-Quiros, C;Gardner, JW;Gardner, KA;Gargiulo, J;Garron, A;Garufi, F;Garver, PA;Gasbarra, C;Gateley, B;Gautier, F;Gayathri, V;Gayer, T;Gemme, G;Gennai, A;Gennari, V;George, J;George, R;Gerberding, O;Gergely, L;Ghosh, Archisman;Ghosh, Sayantan;Ghosh, Shaon;Ghosh, Shrobana;Ghosh, Suprovo;Ghosh, Tathagata;Giaime, JA;Giardina, KD;Gibson, DR;Gibson, DT;Gier, C;Gkaitatzis, S;Glanzer, J;Glotin, F;Godfrey, J;Godwin, P;Goettel, AS;Goetz, E;Golomb, J;Lopez, S Gomez;Goncharov, B;Gong, Y;Gonzalez, G;Goodarzi, P;Goode, S;Goodwin-Jones, AW;Gosselin, M;Gouaty, R;Gould, DW;Govorkova, K;Goyal, S;Grace, B;Grado, A;Graham, V;Granados, AE;Granata, M;Granata, V;Gras, S;Grassia, P;Gray, A;Gray, C;Gray, R;Greco, G;Green, AC;Green, SM;Green, SR;Gretarsson, AM;Gretarsson, EM;Griffith, D;Griffiths, WL;Griggs, HL;Grignani, G;Grimaud, C;Grote, H;Grunewald, S;Guerra, D;Guetta, D;Guidi, GM;Guimaraes, AR;Gulati, HK;Gulminelli, F;Gunny, AM;Guo, H;Guo, W;Guo, Y;Gupta, Anchal;Gupta, Anuradha;Gupta, I;Gupta, NC;Gupta, P;Gupta, SK;Gupta, T;Gupta, V;Gupte, N;Gurs, J;Gutierrez, N;Guzman, F;Haba, D;Haberland, M;Haino, S;Hall, ED;Hamilton, EZ;Hammond, G;Han, W-B;Haney, M;Hanks, J;Hanna, C;Hannam, MD;Hannuksela, OA;Hanselman, AG;Hansen, H;Hanson, J;Harada, R;Hardison, AR;Harikumar, S;Haris, K;Harmark, T;Harms, J;Harry, GM;Harry, IW;Hart, J;Haskell, B;Haster, C-J;Haughian, K;Hayakawa, H;Hayama, K;Hayes, R;Heffernan, A;Heintze, MC;Heinze, J;Heinzel, J;Heitmann, H;Hellman, F;Helmling-Cornell, AF;Hemming, G;Henderson-Sapir, O;Hendry, M;Heng, IS;Hennig, MH;Henshaw, C;Heurs, M;Hewitt, AL;Heyns, J;Higginbotham, S;Hild, S;Hill, S;Himemoto, Y;Hirata, N;Hirose, C;Hochheim, S;Hofman, D;Holland, NA;Holz, DE;Honet, L;Hong, C;Hoshino, S;Hough, J;Hourihane, S;Howard, NT;Howell, EJ;Hoy, CG;Hrishikesh, CA;Hsieh, H-F;Hsieh, H-Y;Hsiung, C;Hsu, W-F;Hu, Q;Huang, HY;Huang, Y;Huang, YT;Huddart, AD;Hughey, B;Hui, DCY;Hui, V;Husa, S;Huxford, R;Iampieri, L;Iandolo, GA;Ianni, M;Ierardi, A;Iess, A;Imafuku, H;Inayoshi, K;Inoue, Y;Iorio, G;Iosif, P;Iqbal, MH;Irwin, J;Ishikawa, R;Isi, M;Itoh, Y;Iwanaga, H;Iwaya, M;Iyer, BR;Jacquet, C;Jacquet, P-E;Jadhav, SJ;Jadhav, SP;Jain, T;James, AL;James, PA;Jamshidi, R;Jani, K;Janquart, J;Janssens, K;Janthalur, NN;Jaraba, S;Jaranowski, P;Jaume, R;Javed, W;Jennings, A;Jia, W;Jiang, J;Johanson, C;Johns, GR;Johnson, NA;Johnston, MC;Johnston, R;Johny, N;Jones, DH;Jones, DI;Jones, EJ;Jones, R;Jose, S;Joshi, P;Joshi, SK;Ju, J;Ju, L;Jung, K;Junker, J;Juste, V;Kabagoz, HB;Kajita, T;Kaku, I;Kalogera, V;Kalomenopoulos, M;Kamiizumi, M;Kanda, N;Kandhasamy, S;Kang, G;Kannachel, NC;Kanner, JB;Kapadia, SJ;Kapasi, DP;Karat, S;Kashyap, R;Kasprzack, M;Kastaun, W;Kato, T;Katsavounidis, E;Katzman, W;Kaushik, R;Kawabe, K;Kawamoto, R;Kazemi, A;Kedia, A;Keitel, D;Kennington, J;Kesharwani, R;Key, JS;Khadela, R;Khadka, S;Khalili, FY;Khan, F;Khan, I;Khanam, T;Khursheed, M;Khusid, NM;Kiendrebeogo, W;Kijbunchoo, N;Kim, C;Kim, JC;Kim, K;Kim, MH;Kim, S;Kim, Y-M;Kimball, C;Kinley-Hanlon, M;Kinnear, M;Kissel, JS;Klimenko, S;Knee, AM;Knust, N;Kobayashi, K;Koch, P;Koehlenbeck, SM;Koekoek, G;Kohri, K;Kokeyama, K;Koley, S;Kolitsidou, P;Komori, K;Kong, AKH;Kontos, A;Korobko, M;Kossak, RV;Kou, X;Koushik, A;Kouvatsos, N;Kovalam, M;Kozak, DB;Kranzhoff, SL;Kringel, V;Krishnendu, NV;Krolak, A;Kruska, K;Kubisz, J;Kuehn, G;Kulkarni, S;Ramamohan, A Kulur;Kumar, A;Kumar, Praveen;Kumar, Prayush;Kumar, Rahul;Kumar, Rakesh;Kume, J;Kuns, K;Kuntimaddi, N;Kuroyanagi, S;Kuwahara, S;Kwak, K;Kwan, K;Kwon, J;Lacaille, G;Lagabbe, P;Laghi, D;Lai, S;Lalande, E;Lalleman, M;Lalremruati, PC;Landry, M;Landry, P;Lane, BB;Lang, RN;Lange, J;Langgin, R;Lantz, B;La Rana, A;Rosa, IL;Larsen, J;Lartaux-Vollard, A;Lasky, PD;Lawrence, J;Lawrence, MN;Laxen, M;Lazarte, C;Lazzarini, A;Lazzaro, C;Leaci, P;Leali, L;Lecoeuche, YK;Lee, HM;Lee, HW;Lee, J;Lee, K;Lee, R-K;Lee, R;Lee, Sungho;Lee, Sunjae;Lee, Y;Legred, IN;Lehmann, J;Lehner, L;Le Jean, M;Lemaitre, A;Lenti, M;Leonardi, M;Lequime, M;Leroy, N;Lesovsky, M;Letendre, N;Lethuillier, M;Levin, Y;Leyde, K;Li, AKY;Li, KL;Li, TGF;Li, X;Li, Y;Li, Z;Lihos, A;Lin, C-Y;Lin, ET;Lin, LC-C;Lin, Y-C;Lindsay, C;Linker, SD;Littenberg, TB;Liu, A;Liu, GC;Liu, Jian;Villarreal, F Llamas;Llobera-Querol, J;Lo, RKL;Locquet, J-P;Loizou, MR;London, LT;Longo, A;Lopez, D;Portilla, M Lopez;Lorenzini, M;Lorenzo-Medina, A;Loriette, V;Lormand, M;Losurdo, G;Lotti, E;Lott, TP;Lough, JD;Loughlin, HA;Lousto, CO;Low, N;Lowry, MJ;Lu, N;Lucchesi, L;Luck, H;Lumaca, D;Lundgren, AP;Lussier, AW;Ma, L-T;Ma, S;Macas, R;Macedo, A;MacInnis, M;Maciy, RR;Macleod, DM;MacMillan, IAO;Macquet, A;Macri, D;Maeda, K;Maenaut, S;Magare, SS;Magee, RM;Maggio, E;Maggiore, R;Magnozzi, M;Mahesh, M;Maini, M;Majhi, S;Majorana, E;Makarem, CN;Malakar, D;Malaquias-Reis, JA;Mali, U;Maliakal, S;Malik, A;Mallick, L;Malz, A;Man, N;Mandic, V;Mangano, V;Mannix, B;Mansell, GL;Mansingh, G;Manske, M;Mantovani, M;Mapelli, M;Marchesoni, F;Marinelli, C;Pina, D Marin;Marion, F;Marka, S;Marka, Z;Markosyan, AS;Markowitz, A;Maros, E;Marsat, S;Martelli, F;Martin, IW;Martin, RM;Martinez, BB;Martinez, M;Martinez, V;Martini, A;Martins, JC;Martynov, DV;Marx, EJ;Massaro, L;Masserot, A;Masso-Reid, M;Mastrodicasa, M;Mastrogiovanni, S;Matcovich, T;Matiushechkina, M;Matsuyama, M;Mavalvala, N;Maxwell, N;McCarrol, G;McCarthy, R;McClelland, DE;McCormick, S;McCuller, L;McEachin, S;McElhenny, C;McGhee, GI;McGinn, J;McGowan, KBM;McIver, J;McLeod, A;McRae, T;Meacher, D;Meijer, Q;Melatos, A;Mellaerts, S;Menoni, CS;Mera, F;Mercer, RA;Mereni, L;Merfeld, K;Merilh, EL;Merou, JR;Merritt, JD;Merzougui, M;Messenger, C;Messick, C;Mestichelli, B;Meyer-Conde, M;Meylahn, F;Mhaske, A;Miani, A;Miao, H;Michaloliakos, I;Michel, C;Michimura, Y;Middleton, H;Miller, SJ;Millhouse, M;Milotti, E;Milotti, V;Minenkov, Y;Mio, N;Mir, Ll M;Mirasola, L;Miravet-Tenes, M;Miritescu, C-A;Mishra, AK;Mishra, A;Mishra, C;Mishra, T;Mitchell, AL;Mitchell, 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GWTC-4.0: Population Properties of Merging Compact Binaries. Astrophysical Journal Letters; 2026; Vol. 1005; iss. 2
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Constraints on Gravitational Waves from the 2024 Vela Pulsar Glitch. Astrophysical Journal; 2026; Vol. 1005; iss. 1
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GW230814: Investigation of a Loud Gravitational-wave Signal Observed with a Single Detector. Astrophysical Journal Letters; 2026; Vol. 1004; iss. 2
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GWTC-4.0: Updating the Gravitational-wave Transient Catalog with Observations from the First Part of the Fourth LIGO-Virgo-KAGRA Observing Run. Astrophysical Journal Letters; 2026; Vol. 1004; iss. 2
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GWTC-4.0: Methods for Identifying and Characterizing Gravitational-wave Transients. Astrophysical Journal Letters; 2026; Vol. 1004; iss. 2
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B;Bankar, D;Baptiste, TM;Baral, P;Baratti, M;Barayoga, JC;Barish, BC;Barker, D;Barman, N;Barneo, P;Barone, F;Barr, B;Barsotti, L;Barsuglia, M;Barta, D;Bartoletti, AM;Barton, MA;Bartos, I;Basalaev, A;Bassiri, R;Basti, A;Bawaj, M;Baxi, P;Bayley, JC;Baylor, AC;Baynard, PA;Bazzan, M;Bedakihale, VM;Beirnaert, F;Bejger, M;Belardinelli, D;Bell, AS;Bellie, DS;Bellizzi, L;Benoit, W;Bentara, I;Bentley, JD;Ben Yaala, M;Bera, S;Bergamin, F;Berger, BK;Bernuzzi, S;Beroiz, M;Berry, CPL;Bersanetti, D;Bertheas, T;Bertolini, A;Betzwieser, J;Beveridge, D;Bevilacqua, G;Bevins, N;Bhandare, R;Bhatt, R;Bhattacharjee, D;Bhattacharyya, S;Bhaumik, S;Biancalana, V;Bianchi, A;Bilenko, IA;Billingsley, G;Binetti, A;Bini, S;Binu, C;Biot, S;Birnholtz, O;Biscoveanu, S;Bisht, A;Bitossi, M;Bizouard, M-A;Blaber, S;Blaber, S;Blackburn, JK;Blagg, LA;Blair, CD;Blair, DG;Bode, N;Boettner, N;Boileau, G;Boldrini, M;Bolingbroke, GN;Bolliand, A;Bonavena, LD;Bondarescu, R;Bondu, F;Bonilla, E;Bonilla, MS;Bonino, A;Bonnand, R;Borchers, A;Borhanian, S;Boschi, V;Bose, S;Bossilkov, V;Bothra, Y;Boudon, A;Bourg, L;Bouyer, G;Boyle, M;Bozzi, A;Bradaschia, C;Brady, PR;Branch, A;Branchesi, M;Braun, I;Briant, T;Brillet, A;Brinkmann, M;Brockill, P;Brockmueller, E;Brooks, AF;Brown, BC;Brown, DD;Brozzetti, ML;Brunett, S;Bruno, G;Bruntz, R;Bryant, J;Bu, Y;Bucci, F;Buchanan, J;Bulashenko, O;Bulik, T;Bulten, HJ;Buonanno, A;Burtnyk, K;Buscicchio, R;Buskulic, D;Buy, C;Byer, RL;Davies, GS Cabourn;Cabrita, R;Caceres-Barbosa, V;Cadonati, L;Cagnoli, G;Cahillane, C;Calafat, A;Callister, TA;Calloni, E;Callos, SR;Canepa, M;Caneva Santoro, G;Cannon, KC;Cao, H;Capistran, LA;Capocasa, E;Capote, E;Capurri, G;Carapella, G;Carbognani, F;Carlassara, M;Carlin, JB;Carlson, TK;Carney, MF;Carpinelli, M;Carrillo, G;Carter, JJ;Carullo, G;Casallas-Lagos, A;Diaz, J Casanueva;Casentini, C;Castro-Lucas, SY;Caudill, S;Cavaglia, M;Cavalieri, R;Ceja, A;Cella, G;Cerda-Duran, P;Cesarini, E;Chabbra, N;Chaibi, W;Chakraborty, A;Chakraborty, P;Chakraborty, S;Subrahmanya, S Chalathadka;Chan, JCL;Chan, M;Chang, K;Chao, S;Charlton, P;Chassande-Mottin, E;Chatterjee, C;Chatterjee, Debarati;Chatterjee, Deep;Chaturvedi, M;Chaty, S;Chatziioannou, K;Chen, A;Chen, AH-Y;Chen, D;Chen, H;Chen, HY;Chen, S;Chen, Yanbei;Chen, Yitian;Cheng, HP;Chessa, P;Cheung, HT;Cheung, SY;Chiadini, F;Chiarini, G;Chiba, A;Chincarini, A;Chiofalo, ML;Chiummo, A;Chou, C;Choudhary, S;Christensen, N;Chua, SSY;Ciani, G;Ciecielag, P;Cieslar, M;Cifaldi, M;Cirok, B;Clara, F;Clark, JA;Clarke, TA;Clearwater, P;Clesse, S;Cleva, F;Coccia, E;Codazzo, E;Cohadon, P-F;Colace, S;Colangeli, E;Colleoni, M;Collette, CG;Collins, J;Colloms, S;Colombo, A;Compton, CM;Connolly, G;Conti, L;Corbitt, TR;Cordero-Carrion, I;Corezzi, S;Cornish, NJ;Coronado, I;Corsi, A;Cottingham, R;Coughlin, MW;Couineaux, A;Couvares, P;Coward, DM;Coyne, R;Cozzumbo, A;Creighton, JDE;Creighton, TD;Cremonese, P;Crook, S;Crouch, R;Csizmazia, J;Cudell, JR;Cullen, TJ;Cumming, A;Cuoco, E;Cusinato, M;Da 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SE;Eassa, C;Ebersold, M;Eckhardt, T;Eddolls, G;Effler, A;Eichholz, J;Einsle, H;Eisenmann, M;Emma, M;Endo, K;Enficiaud, R;Errico, L;Espinosa, R;Espitia, MC;Esposito, M;Essick, RC;Estelles, H;Etzel, T;Evans, M;Evstafyeva, T;Ewing, BE;Ezquiaga, JM;Fabrizi, F;Fafone, V;Fairhurst, S;Farah, AM;Farr, B;Farr, WM;Favaro, G;Favata, M;Fays, M;Fazio, M;Feicht, J;Fejer, MM;Felicetti, R;Fenyvesi, E;Fernandes, J;Fernandes, T;Fernando, D;Ferraiuolo, S;Ferreira, TA;Fidecaro, F;Figura, P;Fiori, A;Fiori, I;Fishbach, M;Fisher, RP;Fittipaldi, R;Fiumara, V;Flaminio, R;Fleischer, SM;Fleming, LS;Floden, E;Fong, H;Font, JA;Fontinele-Nunes, F;Foo, C;Fornal, B;Franceschetti, K;Frappez, F;Frasca, S;Frasconi, F;Freed, JP;Frei, Z;Freise, A;Freitas, O;Frey, R;Frischhertz, W;Fritschel, P;Frolov, VV;Fronze, GG;Fuentes-Garcia, M;Fujii, S;Fujimori, T;Fulda, P;Fyffe, M;Gadre, B;Gair, JR;Galaudage, S;Galdi, V;Gamba, R;Gamboa, A;Gamoji, S;Ganapathy, D;Ganguly, A;Garaventa, B;Garcia-Bellido, J;Garcia-Quiros, C;Gardner, 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    LIRIAS4433857
    description

    Publisher: IOP Publishing Ltd
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  • journal-article
    Lombardi, Pasquale;Ramon-Gil, Erik;Raja, Rabial Q;Brunetti, Leonardo;Manfredi, Giulia Francesca;Zhou, Zhongguo;Merces, George;Cappuyns, Sarah;Maria Fulgenzi, Claudia Angela;D'Alessio, Antonio;Torkpour, Aria;Celsa, Ciro;Stefanini, Bernardo;Yang, Hannah;Crowley, Fionnuala;Marron, Thomas U;Saeed, Anwaar;Pinter, Matthias;Scheiner, Bernhard;Huang, Yi-Hsiang;Lee, Pei-Chang;Nishida, Naoshi;Po-Ting Lin, Ryan;Dalbeni, Andrea;Vivaldi, Caterina;Masi, Gianluca;Rohlen, Natascha;von Felden, Johann;Kaseb, Ahmed;Galle, Peter R;Kudo, Masatoshi;Hsu, Wei-Fan;Rimassa, Lorenza;Parisi, Alessandro;Kelley, Robin Kate;Toyoda, Hidenori;Pirisi, Mario;Jabar, Falah;Rakaee, Mehrdad;Cabibbo, Giuseppe;Cammà, Calogero;Piscaglia, Fabio;Hwang, Sohyun;Shin, Dong Jun;Li, Michael;Dekervel, Jeroen;Guerra, Nadia;Meyer, Tim;Reeves, Helen L;Bengsch, Bertram;Daniele, Gennaro;Mann, Derek A;Chon, Hong Jae;Leslie, Jack;Pinato, David J; 2026. A myeloid immunosuppressive phenotype defines primary refractoriness to atezolizumab plus bevacizumab in hepatocellular carcinoma.. J Hepatol; 2026; pp. S0168-8278(26)02605-X - ...
    LIRIAS4429168
    description
    BACKGROUND & AIMS: Despite improved outcomes with atezolizumab plus bevacizumab (A+B) in hepatocellular carcinoma, primary refractoriness (PRef), characterised by early progression or short-lived disease stabilisation following treatment, remains a significant challenge. METHODS: We analysed 1,296 patients with hepatocellular carcinoma treated with frontline A+B (AB-real) and validated findings in 645 trial participants recruited to IMbrave150 and GO30140. PRef was defined by SITC (Society for the Immunotherapy of Cancer) criteria. We performed a multi-parametric analysis of pre-treatment tumour tissue, including machine learning-based quantification of tumour-infiltrating lymphocytes, imaging mass cytometry and RNA sequencing (RNA-seq) to evaluate differences in the tumour microenvironment (TME) of patients with PRef vs. responders. Two independent cohorts were further used to refine the TME characterisation through single-cell RNA-seq (n = 20) and imaging mass cytometry (n = 16). We employed conditional inference tree analyses to provide a hierarchical organisation of PRef determinants. RESULTS: Among 677 AB-real patients and 378 trial participants evaluable by SITC criteria, PRef was associated with inferior median overall survival compared to response (AB-real: 7.3 vs. 31.5 months, p <0.001; Trials: 10.8 vs. not reached, p <0.001). Patients with PRef exhibited higher baseline systemic inflammation (neutrophil-to-lymphocyte ratio [NLR] ≥3), a distinctly immunosuppressive TME enriched in CD163+ tumour-associated macrophages and vascular cancer-associated fibroblasts, a higher Treg/Teff cell ratio, and pro-tumour supportive cellular interactions. RNA-seq of tumour tissue confirmed lower intrinsic immunogenicity in PRef samples with elevated myeloid infiltration. Conditional inference tree analysis identified IFN-γ signature downregulation combined with NLR ≥3 as the strongest contributor of PRef. CONCLUSIONS: PRef to A+B identifies a distinct biological entity characterised by unopposed systemic inflammation, myeloid infiltration, and T-cell depletion. Targeting myeloid-mediated immunosuppression, particularly in patients with low IFN-γ signature expression and elevated NLR might enhance responsiveness to A+B. IMPACT AND IMPLICATIONS: Atezolizumab plus bevacizumab represents the standard first-line treatment for unresectable hepatocellular carcinoma, yet the biological basis of early treatment failure remains poorly understood. In this multi-cohort translational study, we show that approximately 40% of patients exhibit primary refractoriness according to SITC criteria - clinically validated here for the first time in hepatocellular carcinoma - and identify a distinct immuno-molecular profile of primary refractory tumours characterised by IFN-γ pathway repression, unfavourable myeloid polarisation, and a distinct spatial immune architecture. These findings provide a biological framework that may inform the design of biomarker-stratified trials and rational combination strategies to overcome primary resistance to first-line immunotherapy.

    Published online
  • presentation
    Pfister, M;Eden, J;Rasel, H;Abbassi, F;Botea, F;Buchholz, B;Camagni, S;Chapman, W;Cillo, U;Cimeno, A;Compagnon, P;Croome, K;de Carlis, R;Diogo, D;Dondossola, D;Fung, J;Fronek, J;Garcia, C;Gyori, G;Koliogiannis, D;Lam, HD;Lurje, G;Magistri, P;Monbaliu, D;Patel, M;Patrono, D;Porte, R;Ravaioli, M;Rayar, M;Satish, S;Schlegel, A;Shapiro, J;Sorensen, G;Vaccharajani, N;Vagefi, P;Pinna, A;Dutkowski, P;de Meijer, V;Clavien, PA; 2026. Real World Analysis of Machine Perfusion in Liver Transplantation - An International Cohort Study. British Journal Of Surgery; 2026; Vol. 113 Publisher: Scandinavian University Press
    LIRIAS4426834
    description


    Published
  • journal-article
    Gómez Rivas, J;Gómez Dávila, P;Tarrazo Antelo, AM;Corujo Quinteiro, M;Gómez Amorín, Á;Rodríguez Alonso, A;Vilaseca, JM;López, H;Salazar, JP;Borque-Fernando, Á;Moreno-Sierra, J;Collen, S;Beyer, K;Helleman, J;Roobol, MJ;van Poppel, H;en representación de PRAISE-U Consortium, ; 2026. Past and present of prostate cancer screening in the European Union.. Actas Urol Esp (Engl Ed); 2026; Vol. 50; iss. 5; pp. 501897 - ...
    LIRIAS4394510
    description
    INTRODUCTION: Prostate cancer (PCa) screening based on prostate-specific antigen (PSA) testing has represented a major milestone in early detection; however, it has also prompted considerable debate due to the risks of overdiagnosis and overtreatment. This review examines the evolution of PCa screening, highlighting its main challenges and emerging approaches aimed at achieving more accurate and individualized detection. METHODS: A narrative review of the literature was conducted using databases such as PubMed and Google Scholar, applying MeSH terms related to screening, overdiagnosis, and prostate cancer. Clinical studies, systematic reviews, and recent guidelines pertinent to the topic were included. RESULTS: The PLCO, ERSPC, and Göteborg trials provide complementary insights into the impact of PSA-based screening, with outcomes ranging from limited benefit to significant reductions in PCa-specific mortality. Based on these this findings, a paradigm shift toward risk-stratified screening strategies has been advocated. The incorporation of new tools such as magnetic resonance imaging, blood and urine biomarkers, risk calculators, and artificial intelligence-based algorithms has improved diagnostic accuracy. These strategies reduce unnecessary biopsies and focus on the detection of clinically significant disease. Current guidelines recommend individualized assessment based on factors such as age, baseline PSA levels, family history, and comorbidities. CONCLUSION: The future of PCa screening resides in personalized medicine, in which the integration of clinical, imaging, and molecular parameters will enable a more efficient approach, minimizing unnecessary interventions and improving overall patient outcomes.

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